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血清和组织光链作为AL Amyloidosis中的疾病生物标志物

Alberto Aimo1,2, Yu Fu Ferrari Chen1,2,3, Michela Chianca3

  • 1Health Sciences Interdisciplinary Center, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.

International journal of molecular sciences
|October 16, 2025
PubMed
概括

粉样蛋白轻链粉样蛋白症的诊断依赖于检测器官和血液中错误折叠的免疫球蛋白轻链 (LC). 测量流通的自由液晶体 (FLC) 和分析组织沉积物是评估和管理的关键.

关键词:
在AL氨基粉症症.粉样蛋白纤维的纤维.免费的光链.心脏衰竭是因为心脏衰竭.免疫球蛋白是一种免疫球蛋白.血细胞疾病 血细胞疾病

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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