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布拉西卡提取物通过调节反应性氧物种和自性来防止类烯诱导的转化

José Benito Montes-Alvarado¹, Paula Garcia-Ibañez², Diego A Moreno³

¹Biotechnology Laboratory, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico.

International journal of molecular sciences

|October 16, 2025

概括

富含有益化合物的西兰花芽和红菜提取物可以防止由致癌物引起的细胞变化. 红菜提取物还可以激活自,这是一种抑制瘤的途径.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
营养科学营养科学

背景情况:

棕植物含有葡萄糖酸盐 (GSL),产生异硫酸酸盐 (ITC) 和具有抗炎和抗氧化功能的内醇.
甲 (B) 是一种致癌物质,可诱导活性氧物种 (ROS) 和DNA损伤,从而促进细胞转化.

研究的目的:

为了研究西兰花芽提取物 (BSE) 和红菜水性提取物 (RCA) 对MCF10A细胞中B(a) P诱导的细胞转化的影响.
确定这些提取物是否可以减轻B(a) P诱导的增殖,ROS产生,并诱导自.

主要方法:

利用MCF10A细胞,一种非瘤源的乳腺细胞系,作为细胞转化模型.
用B(a) P处理的细胞,然后用BSE或RCA提取物进行治疗.
评估了细胞增殖,ROS生产和自诱导.

主要成果:

无论是BSE还是RCA提取物都显著降低了B(a) P诱导的细胞增殖和ROS生产.
发现RCA提取物可在MCF10A细胞中诱导自.
提取物的有效性归因于它们的高ITC和醇化合物含量.

结论:

牛脊髓灰质炎和RCA提取物显示出防止致癌物诱导的细胞转变的潜力.
RCA提取物可以作为一种诱导自的方法,这是一个已知的瘤抑制途径.

关键词:

黄铜 (Brassicas) 是一种自自是自的过程.乳腺癌乳腺癌乳腺癌菜和西兰花是不同的.卷心菜卷心菜卷心菜有活性氧物种的反应性氧物种.

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