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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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估计功能对内皮功能障碍和亚临床炎症的贡献,采用两组队列研究:活着的脏捐赠者和他们的移植接受者
Irina B Torres1,2, Carla Burballa3, José M González-Posada4
1Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
International journal of molecular sciences
|October 16, 2025
概括
活体脏捐赠会影响脏功能,导致捐赠者的内皮功能障碍和炎症标志物增加. 接收者在移植后显示标记物减少,突出显示需要进行长期心血管风险评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 活体脏移植是对末期脏疾病的最佳选择.
- 人们担心,脏切除术后的脏捐赠者存在心血管风险.
- 功能在移植后内皮功能障碍和炎症中的作用需要研究.
研究的目的:
- 评估功能对内皮功能障碍 (ED) 和活体捐赠者和接受者的亚临床炎症的贡献.
- 在脏捐赠和移植后纵向跟踪ED和炎症生物标志物的变化.
主要方法:
- 对50对捐赠者-接受者对进行前性,多中心的纵向研究.
- 通过iohexol清除测量了淋巴膜过率 (mGFR) 和估计的GFR (CKD-EPI,MDRD-4).
- 在基线和1年随访期间评估ED生物标志物 (sVCAM-1,sICAM-1,E-selectin,vWF,pentraxin,UACR) 和炎症生物标志物 (sIL-6,sTNFR1,sTNFR2,sTWEAK,hs-CRP).
主要成果:
- 捐赠者的sVCAM-1增加,而接受者的sVCAM-1降低 (p < 0.01).
- 在捐赠者中,sTNFR1和sTNFR2显著增加,在接受者中显著减少 (p < 0.001).
- 在捐赠者中观察到ED和炎症标志物的并行增加,在接受者中观察到移植后的减少.
结论:
- 脏捐赠与捐赠者的ED和亚临床炎症标志物增加有关.
- 接收者在移植后表现出ED和炎症标志物的降低.
- 长期跟踪至关重要,以充分描述与这些生物标志物变化相关的心血管风险.
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