独特的B细胞子集变化作为克罗恩病对生物疗法反应的潜在生物标志物
Anna Helmin-Basa1, Maria Kopoń2, Jarosław Koza2,3
1Department of Immunology, Faculty of Farmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
克罗恩病 (CD) 患者的基线免疫细胞水平预测了对生物疗法的反应,如infliximab和vedolizumab. 特定的T和B细胞子集变化表明治疗的有效性和独特的治疗机制.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物疗法,包括Infliximab,Adalimumab和Vedolizumab,用于克罗恩病 (CD),但具有不同的疗效.
- 对治疗反应的预测生物标志物有限,特别是在调节性免疫细胞方面.
研究的目的:
- 调查基线循环T和B细胞子集是否可以预测活跃的,耐治疗的CD患者对生物疗法的反应.
- 为了确定免疫细胞对不同生物药物的反应的相关性.
主要方法:
- 血液样本中的T和B细胞子集的流细胞计分析来自43名CD患者和16名健康对照在基线和治疗12-14周后.
- 免疫细胞频率,疾病活性 (CDAI) 和治疗反应之间的相关性分析.
主要成果:
- 在基线,CD患者的记忆B细胞,CD5+CD1d+B细胞,血质细胞和过渡性B细胞减少.
- 过渡性B细胞与calprotectin/血小板负相关;CD5+CD1d+B细胞与calprotectin负相关.
- 因弗利西马布/阿达利穆马布治疗减少了成熟的原始B细胞和增加了CD24hiCD27+B细胞;维多利祖马布增加了血质细胞. 观察到与治疗特定的免疫相关性.
结论:
- 基线B细胞子集水平可以作为生物标志物,用于预测CD中对生物疗法的反应.
- 显著的免疫细胞变化与infliximab/adalimumab与vedolizumab治疗相关,表明不同的作用机制.
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