性激素和代谢功能障碍相关的脂肪性肝病
Ralf Weiskirchen1, Amedeo Lonardo2
1Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, D-52074 Aachen, Germany.
International journal of molecular sciences
|October 16, 2025
概括
性激素显著影响代谢功能障碍相关的脂肪性肝病 (MASLD) 的发展和进展. 了解这些角色对于针对性别的临床方法来管理MASLD至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 性医学 性医学 性医学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 的管理往往忽视了性激素的复杂作用.
- 专家可能缺乏关于性激素对MASLD病原和临床轨迹的影响的全面知识.
研究的目的:
- 审查MASLD中关键性激素 (,雌激素,孕激素) 和性激素结合球蛋白 (SHBG) 的分子作用.
- 探索性激素对各种代谢和炎症途径的影响,这些途径与MASLD有关.
- 检查性激素和MASLD风险之间的关联,考虑生殖状况和诸如多囊性卵巢综合征等特定疾病.
主要方法:
- 关于性激素对肝功能分子作用的文献综述.
- 对观察性研究的分析,将内源性和外源性激素和SHBG与MASLD联系起来.
- 对不同生命阶段和生殖状态中MASLD风险的性别激素调节数据的综合.
主要成果:
- 性激素影响脂肪酸代谢,肠道微生物群,线粒体功能和MASLD中的葡萄糖脂质平衡.
- SHBG在MASLD组织生成中发挥作用,有显著的基于性别的差异.
- 双胞胎缺血症和多囊卵巢综合征与改变的MASLD风险有关,受性激素的影响.
结论:
- 性激素是MASLD病理生物学不可或缺的组成部分,影响其发展,进展和瘤发生.
- 临床实践和研究需要性别特定的策略来有效管理MASLD.
- 激素替代疗法 (HRT) 和避孕药在MASLD中的作用需要进一步研究.
相关概念视频
Overview of Lipid Metabolism
4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K
Liver Physiology
3.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.5K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
180
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
180
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
211
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
211
Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K
Overview of Fatty Acid Metabolism
36.4K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
36.4K


