阿洛格利普丁在老鼠模型中减轻甲甲酸诱导的毒性:对抗氧化应激,炎症和亡
Marwa M Fahmy1, Heba A Habib2, Esraa M Zeidan2
1Minia University Hospital, Minia University, Minia 61519, Egypt.
International journal of molecular sciences
|October 16, 2025
概括
阿洛格利丁 (ALO) 可能会保护脏免受美托特雷克萨特 (MTX) 造成的损伤. 在接受MTX治疗的老鼠中,ALO改善了功能,并减少了氧化应激和炎症的标志物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 甲基 (MTX) 是治疗癌症和炎症疾病的重要药物.
- MTX的使用受到严重毒性 (毒性) 的限制.
- 类型2糖尿病药物阿洛格利丁 (ALO) 正在探索其保护作用.
研究的目的:
- 在大鼠中研究阿洛格利普丁对MTX诱导的毒性有保护作用.
- 探索阿洛格利普丁潜在脏保护作用的潜在机制.
主要方法:
- 四组大鼠:对照组,ALO,MTX和MTX + ALO. 这四组大鼠被分为四组:对照组,ALO,MTX和MTX + ALO.
- 在第7天,MTX (20 mg/kg) 通过腹膜内注射.
- ALO (20 mg/kg/天) 已通过胃内给药10天.
主要成果:
- MTX引发了显著的损伤,功能受损,并改变了氧化应激标志物.
- 麻醉MTX降低了Nrf2/HO-1的表达和增加了KIM-1,TNF-α,和c-caspase-3.
- ALO治疗改善了功能,组织学,氧化平衡,并调节了关键分子通路.
结论:
- 阿洛格利普丁可以抵消MTX诱导的损伤.
- ALO的保护作用包括恢复氧化平衡,抑制亡和炎症.
- ALO显示出作为治疗药物来管理MTX毒性的潜力.
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