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在二氧化酶中活性位点循环的 conformational 动力学突出显示了用于抑制剂对接的循环结构的局限性

Yen-Hua Huang1, Tsai-Ying Huang1,2, Man-Cheng Wang1

  • 1Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 40201, Taiwan.

International journal of molecular sciences
|October 16, 2025
PubMed
概括

氨酶 (DHOase) 循环的灵活性会影响抑制剂的结合. 了解这些结构变化对于有效的基于结构的药物设计和查至关重要.

关键词:
5 - - 酸酸是一种酸.活动站点循环活动站点循环.构造动力学 构造动力学它们是二基酸酶.停靠的对接方式这种药物是myricetin.

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