相关实验视频

Updated: Jan 15, 2026

Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria

Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria

Published on: May 25, 2022

结肠直肠癌中的Fusobacterium Nucleatum:免疫调节,潜在生物标志物和治疗影响之间的关系

Dalila Incognito¹, Giuliana Ciappina², Claudia Gelsomino¹

¹Medical Oncology Unit, Department of Human Pathology "G. Barresi", School of Specialization in Medical Oncology, University of Messina, 98122 Messina, Italy.

International journal of molecular sciences

|October 16, 2025

概括

菌核素 (Fn) 驱动着结直肠癌 (CRC) 的进展和治疗耐药性,特别是在微卫星稳定的瘤中. 向Fn为CRC的新型诊断和治疗提供了潜力.

科学领域:

微生物学微生物学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

菌核素 (Fn) 越来越多地与结直肠癌 (CRC) 的发展和进展有关.
它在微卫星稳定 (MSS) CRC中发挥着重要作用,这种亚型通常对免疫检查点抑制剂 (ICI) 具有抗性.

研究的目的:

阐明Fn在CRC中的多方面的作用,包括瘤进展,免疫逃避和治疗耐药性.
探索Fn作为早期检测和患者分层的潜在生物标志物.
审查针对CRC中的Fn的新兴治疗策略.

主要方法:

临床前体外和体内研究的综述.
对人类观察数据的分析.
对Fn在CRC中的机制进行当前研究的综合.

主要成果:

通过粘附于上皮细胞,激活瘤性途径,并诱导上皮-介质细胞过渡 (EMT),Fn积极促进CRC.
Fn重塑瘤微环境以抑制抗瘤免疫力并驱动对ICI的抵抗力.
通过促进自和抑制铁亡,Fn有助于化学疗法耐药性.

结论:

在CRC的进展,免疫抑制和对疗法的耐药性方面,Fn是关键因素.
Fn具有作为CRC早期检测和患者分层的生物标志物的潜力.
通过各种策略准Fn可能会提高CRC治疗效率,特别是在MSS瘤中.

关键词:

杆菌核酸 (Fusobacterium nucleatum) 是一种细菌.生物标志物生物标志物结直肠瘤是什么意思药物耐药性耐药性药物耐药性免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法

更多相关视频

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

相关概念视频

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...