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乳腺癌中miR-21的预后能力:系统性审查和元分析

Luana Conte^1,2, Maria Rosaria Tumolo^3,4, Giorgio De Nunzio^5,2

¹Department of Physics and Chemistry "E. Segrè", University of Palermo, 90128 Palermo, Italy.

International journal of molecular sciences

|October 16, 2025

概括

乳腺癌 (BC) 的高miR-21表达与较差的存活率和复发率有关. 这种微RNA (miRNA) 具有预后价值,特别是在像三负BC.这样的侵略性亚型中.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

乳腺癌 (BC) 是全球女性癌症相关死亡的主要原因.
尽管治疗进展,但BC的预后评估仍然具有挑战性,因为其高变异性.
微RNAs (miRNAs) 正在成为改进BC预后的关键分子生物标志物.

研究的目的:

系统地审查和元分析miR-21在乳腺癌的预后意义.
通过生物信息学分析研究miR-21在BC进展中的作用背后的分子机制.

主要方法:

在PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索.
18项观察性研究被纳入了元分析.
进行了生物信息分析,以确定miR-21向基因和相关途径.

主要成果:

高的miR-21表达与较差的整体存活率 (OS) (HR = 2.37) 和无复发存活率 (DFS/RFS) (HR = 2.10) 显著相关.
在三重阴性BC (HR = 5.69) 和混合亚型 (HR = 2.55) 中观察到更强的关联.
在HER2阳性BC中没有发现显著的关联.
生物信息分析确定了关键向基因 (PTEN,BCL2,STAT3,MYC) 参与瘤性途径.

结论:

miR-21是乳腺癌的一个有前途的预后生物标志物,特别是在攻击性的亚型.
它在调节亡,增殖和信号通路方面的作用需要进一步研究.
miR-21有可能被整合到乳腺癌多式预后模型中.

关键词:

生物信息学是一种生物信息学.乳腺癌乳腺癌乳腺癌这是一个元分析.据报道,米R-21的发射器为米R-21 预后预后预后

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