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相关概念视频

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Inflammation01:38

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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Updated: Jan 15, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
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动脉硬性斑块晶体诱导内皮细胞功能障碍

Jishamol Thazhathveettil1, Sherin Aloysius Gomez2, Deborah Olaoseeji3

  • 1Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden.

International journal of molecular sciences
|October 16, 2025
PubMed
概括

胆固醇晶体 (CC) 和单尿酸 (MSU) 等内源性晶体激活内皮细胞,导致炎症和线粒体功能障碍. 这些由晶体诱导的信号是早期动脉样硬化的关键驱动因素.

关键词:
动脉样硬化 动脉样硬化胆固醇晶体 (CC) 是一种内皮质功能障碍 在内皮质功能障碍单酸盐 (MSU) 是一种中性粒细胞外细胞陷 (NETs)

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科学领域:

  • 血管生物学 血管生物学
  • 免疫学 免疫学 免疫学
  • 在疾病中结晶.

背景情况:

  • 内皮功能障碍是动脉样硬化的关键早期阶段.
  • 内源晶体,如胆固醇晶体 (CC) 和单酸盐 (MSU) 在内皮激活中的特定作用尚未完全理解.

研究的目的:

  • 研究CC和MSU对内皮细胞的影响.
  • 为了评估炎症信号,线粒体呼吸和中性粒细胞的招募,以应对晶体刺激.

主要方法:

  • 在剂量和时间控制的实验中,人类脉内皮细胞被暴露在CC和MSU中.
  • 分析包括炎症信号通路 (NF-κB,STAT3),细胞因子概况,线粒体呼吸和中性粒细胞粘附测试.

主要成果:

  • CC和MSU被内皮细胞内化,激活NF-κB和STAT3通路.
  • 晶体诱导了促炎性细胞因子和线粒体呼吸功能受损,特别是CC.
  • 晶体刺激和条件介质促进了内皮粘附分子表达和中性粒细胞粘附.

结论:

  • 晶体刺激作为强大的血管危险信号,诱导内皮炎症和线粒体功能障碍.
  • 这些由晶体诱导的反应有助于血管炎症和免疫细胞参与,这是早期动脉生成的标志.
  • 这项研究为动脉样硬化的早期阶段的晶体驱动血管功能障碍提供了机械的见解.