生殖荷尔蒙失调的功能和进化作用,在饮食中暴露于烧肉肉后
Prosper Manu Abdulai1, Orish Ebere Orisakwe2, Costantino Parisi3
1Department of Public Health Education, Faculty of Environment and Health Education, Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development, Asante Mampong P.O. Box 40, Ghana.
International journal of molecular sciences
|October 16, 2025
概括
用柴火或轮胎烧肉的消费会通过破坏关键激素来损害生殖健康. 液化石油气 (LPG) 烧肉的影响最小,这表明燃料类型对食品安全至关重要.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
背景情况:
- 使用非标准燃料烧肉在低收入和中等收入国家很常见.
- 火柴和轮胎等燃料的燃烧副产品对健康构成风险.
- 烧肉对内分泌调节,特别是生殖激素的影响尚不清楚.
研究的目的:
- 研究食用不同燃料烧肉对生殖激素网络的影响.
- 识别与常见的肉类切割做法相关的潜在健康风险.
主要方法:
- 雄性Wistar大鼠在90天的时间里被养了25%,50%或75%的肉,用柴火,液化天然气或轮胎烧焦.
- 评估肝细胞损伤,蛋白质新陈代谢,功能 (血尿素,肌),器官体重,氧化应激标志物和生殖激素水平 (,FSH,LH,前素).
主要成果:
- 柴火和轮胎肉诱导了剂量依赖的毒性,包括肝损伤,代谢受损,功能障碍,器官缩和氧化应激.
- 荷尔蒙分析显示,丸激素降低,FSH,LH和益生菌激素增加,这表明下丘脑-垂体-阴茎轴中断.
- 使用液化天然气制的肉类消费只导致了轻微的生理变化.
结论:
- 用柴火和轮胎烧焦的肉类由于内分泌干扰,造成了严重的生殖健康风险.
- 生殖激素作为敏感的生物标志物,用于从烧肉中暴露的有毒物质.
- 排卵实践对生育能力和人口健康有潜在的进化影响.
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