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骨髓中的脂肪细胞-瘤相互作用:对转移和治疗的影响

Alhomam Dabaliz¹, Mohammad Nawar Al Hakawati², Najmuddeen Alrashdan³

¹Department of Clinical Skills, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.

International journal of molecular sciences

|October 16, 2025

概括

骨髓脂肪细胞 (BMA) 通过改变骨微环境,积极促进癌症的生长和扩散. 准这些细胞为骨转移提供了新的治疗策略.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
代谢过程中的代谢.

背景情况:

骨转移显著增加癌症发病率和死亡率.
骨髓脂肪细胞 (BMA) 曾经被认为是被动的,但现在已知可以调节瘤的进展和治疗耐药性.
在老化和肥胖个体中,BMAs是丰富的,影响转移性殖民.

研究的目的:

审查BMAs在骨转移中的多方面的作用.
探索BMA如何促进瘤生长,治疗耐药性和骨病理.
讨论针对BMA的潜在治疗策略.

主要方法:

对BMA和骨转移的临床前和临床研究的审查.
分析包括代谢合,阿迪波金分泌和细胞外囊泡释放在内的机制.
检查实验模型,如共同培养和患者衍生的异种移植.

主要成果:

BMAs通过代谢支持,生长因子的分泌 (莱普,IL-6),骨质细胞生成调节和细胞外囊活动促进转移.
BMA扩张与增加的瘤负担和各种癌症的较差结果相关.
通过代谢重编程和药物封存,BMAs促进治疗耐药性.

结论:

BMAs是通过代谢,内分泌和免疫路径的骨转移利基的关键调节者.
向BMAs为抗骨转移的新疗法提供了一个有希望的途径.
需要进一步研究BMA异质性,脂质代谢和免疫代谢相互作用.

关键词:

亚迪波基因 (Adipokine) 是一种可靠的药物.骨髓脂肪细胞骨髓脂肪细胞骨转移的发生.细胞外囊泡中的细胞外囊泡.治疗性抗药性是一种治疗性抗药性.瘤微环境是一个微环境.

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