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Updated: Jan 15, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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组合ERK抑制增强了BRAF突变黑色素瘤中MAPK路径抑制

Corinna Kosnopfel1, Tobias Sinnberg2,3,4, Shrunal Mane2

  • 1Department of Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Münster, Germany.

International journal of molecular sciences
|October 16, 2025
PubMed
概括

用ERK抑制剂向BRAF突变黑色素瘤,如雷沃克桑提尼布,显示出有希望. 将ERK抑制剂与BRAF/MEK抑制剂结合起来,显著改善了细胞亡和生长抑制,特别是在耐性黑色素瘤细胞中.

关键词:
这种BRAF突变是BRAF突变.这是一种ERK抑制剂.通过MAPK路径.药物耐药性 耐药性 药物耐药性治疗黑色素瘤的治疗方法

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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma08:18

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