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Updated: Jan 15, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

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Published on: March 31, 2019

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在CTCF中介于老鼠心中的Cis调节枢纽

Mick Lee1,2, Loïc Mangnier3,4,5,6, Cory C Padilla7

  • 1Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

International journal of molecular sciences
|October 16, 2025
PubMed
概括

这项研究表明,删除CTCF显著重组增强剂活性,并减少小鼠心脏中的 cis 调节枢纽 (CRH). 失去CTCF还会增加跨越拓相关域 (TAD) 边界的CRH,突出显示CTCF在基因调节网络中的作用.

关键词:
活动-每次接触互联调节中心 (cis-regulatory hubs) 的中心ctcfcf 在这里.增强剂是一种增强剂.小鼠心肌细胞 (CM)

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