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在中国人乳中内源性的动态变化跨哺乳期和地理区域

Baorong Chen¹, Kaifeng Li², Xiaodan Wang¹

¹Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing 100193, China.

|October 16, 2025

概括

根据哺乳期和地区,母乳的形状各不相同,影响婴儿的免疫力和生长. 孕产妇的饮食影响抗菌水平,为婴儿营养提供了洞察力.

科学领域:

人类牛奶的蛋白质组学
内源性分析的内源性分析
婴儿营养婴儿营养

背景情况:

母乳的成分对婴儿发育至关重要.
了解牛奶中的内源性对婴儿健康至关重要.
有限的数据存在于不同中国人群的母乳形状.

研究的目的:

为了描述母乳的内源性形状.
为了研究基于哺乳期和地理区域的变化.
探索,母亲的饮食和婴儿的成长之间的相关性.

主要方法:

对母乳样本进行ORBITRAP Fusion Lumos LC-MS/MS分析.
在中国七个地区进行多中心队列研究 (n=200名母亲).
产后2个月和6个月收集的样本.

主要成果:

从621种蛋白质中鉴定出6960种.
聚合性免疫球蛋白受体 (PIGR) 在2个月时更高,表明免疫功能.
观察到区域差异,兰州牛奶显示出更高的β-素 (CASB) 和丁素 (BTN1A1) .

结论:

孕产妇的饮食脂肪摄入量与特定的抗微生物 (CASB变体) 有正相关.
婴儿的生长与一些抗微生物相反相关,但CASB_200-225显示了积极的关联.
结果提供了对母乳和配方设计的人类牛奶的动态的见解.

关键词:

中国城市中国城市.它们是内源性类.人类牛奶是人类的牛奶.哺乳期哺乳期哺乳期孕妇的饮食孕妇的饮食

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