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外体微RNA:诊断潜力和乳腺癌传播中的作用

Svetlana Tamkovich¹, Alexandra Borisova¹, Andrey Shevela¹

¹Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Molecules (Basel, Switzerland)

|October 16, 2025

概括

使用外体的液体活检可以检测早期乳腺癌 (BC). 外体微RNA显示出诊断BC和指导治疗决策的高潜力.

科学领域:

在瘤学瘤学.
生物化学生物化学
分子生物学分子生物学

背景情况:

液体活检为癌症诊断和治疗监测提供了一种非侵入性方法.
外体,小细胞外囊泡 (sEVs),是细胞间通信的关键媒介,也是生物标志物的有前途来源.
来自瘤的外生体富含诸如microRNAs这样的分子,这些分子参与了癌症的进展.

研究的目的:

审查早期乳腺癌 (BC) 诊断当前的局限性.
探索外体微RNA在BC传播中的作用.
突出了外体微RNA在早期BC检测中的诊断潜力.

主要方法:

关于乳腺癌中的液体活检,外体和微RNA研究的文献综述.
对外体微RNA参与癌症特征的分析,如免疫调节和转移.
对外体微RNA的诊断准确性和临床实用性的评估.

主要成果:

外体微RNA与BC进展有关,影响免疫系统,表皮细胞-介质细胞过渡,增殖,入侵,血管新生和转移.
瘤细胞比正常细胞释放更多的外体,促进生物标志物发现.
外体微RNA显示出早期BC检测和治疗指导的巨大潜力.

结论:

外体微RNA是早期乳腺癌诊断的非常有前途的生物标志物.
使用外体微RNA的液体活检可以帮助选择治疗和预后.
需要进一步的研究来将外体微RNA检测转化为乳腺癌管理的临床实践.

关键词:

电动汽车 (EV) 是一个血液血液血液血液血液乳腺癌乳腺癌乳腺癌外基因组是外基因组的组成部分.液体活检活检液体活检这是一个微型RNA.

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