用三聚烯异环衍生物向抗阿波托斯Bcl-2蛋白质:一种联合双对接和分子动力学研究

Marius Mioc1,2, Silvia Gruin3, Armand Gogulescu3

  • 1Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.

PubMed
概括

研究人员选了贝林衍生物,以寻找抗断性BCL-2家族蛋白的抑制剂,这对癌症生长和抵抗至关重要. BOxNaf1和BOxPhCl1显示出作为多向抗癌药物候选人的前景.

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