在功能性便秘中,通过BL-99后生物药物调节肠滑肌细胞功能
Wen Zhao1, Mingkun Liu2, Hanglian Lan3
1Key Laboratory of Functional Dairy, Department of Nutrition and Health, China Agricultural University, Beijing 100190, China.
Foods (Basel, Switzerland)
|October 16, 2025
概括
来自Bifidobacterium animalis BL-99的后生物有效地通过改善肠道运动性和水合来缓解便秘. 关键,Glu-Val和Glu-Leu被确定为调节肠道肌肉细胞功能的活性成分.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 功能性食品 功能性食品
背景情况:
- 后生物质对食品应用和健康益处越来越感兴趣.
- 它们缓解便秘的机制尚未完全理解.
- 生物细菌 (Bifidobacterium animalis) 的亚种. 研究了乳糖BL-99 (BL-99) 衍生后生物.
研究的目的:
- 研究BL-99后生菌对功能性便秘 (FC) 的影响.
- 为了阐明作用的潜在机制.
- 为了确定负责影响的特定生物活性成分.
主要方法:
- 在体内和体外模型被用于评估FC.
- 测量了肠道移动性,便中的水含量和光滑肌肉细胞 (SMC) 亡.
- 分析了收缩反应和肠道SMC的扩散.
- 非向的代谢学发现了生物活性.
主要成果:
- BL-99及其后生物药物显著缓解了FC症状.
- 增强了肠道运动和便中的水含量.
- 肠道肌肉层的厚度增加,SMC亡减少.
- BL-99后生物促进了SMC的扩散,并增强了收缩反应.
- Glu-Val和Glu-Leu被确定为主要活性成分.
结论:
- BL-99后生菌在改善功能性便秘方面表现出显著的有效性.
- 这些后生菌通过增强肠道运动和调节肠道SMC功能来起作用.
- 已识别的Glu-Val和Glu-Leu对于观察到的效果至关重要.
- BL-99后生物质代表了对便秘管理有前途的功能性食品成分.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
712
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
712
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
880
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
880
Drugs for Treatment of Diarrhea-Predominant IBS
625
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
625
Drugs Affecting GI Tract Motility: Other Laxatives
1.0K
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.0K
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
524
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
524
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
564
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
564


