胆囊切除术后结肠直肠癌风险:一个更新的系统性审查
Pierre-Henri Nelis1, Stefano Grotto1, Kenza Azra Ibis1
1Department of Hepatopancreatobiliary Surgery, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel and Europe Hospitals, 1090 Brussels, Belgium.
Cancers
|October 16, 2025
概括
胆囊切除术 (胆囊切除术) 可能与附近结肠癌的更高风险有关,但整体结肠直肠癌风险仍然不确定. 需要更多的研究来证实这种关联.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 胆囊切除术 (CE) 是一种常见的胆结石疾病的手术.
- 人们担心CE和结直肠癌 (CRC) 之间存在潜在的长期联系.
- 之前关于这种关联的研究已经产生了不一致的结果.
研究的目的:
- 系统地审查和更新关于CE和CRC风险之间的关联的证据.
- 将2022年5月之后发表的最新研究成果纳入其中.
主要方法:
- 在主要数据库中按照PRISMA 2020指南进行系统的文献搜索.
- 包括高质量的观察性队列研究,报告CE后的CRC风险.
- 使用纽卡斯尔-太华尺度 (NOS) 和出版偏差分析进行质量评估.
主要成果:
- 更新的综述包括21项高质量的研究.
- 在CE和整体CRC风险之间没有发现一致的关联.
- 几项研究表明,在CE后,近道 (右侧) 结肠癌的风险增加.
结论:
- 建议CE与近壁结肠癌风险增加之间存在潜在的关联.
- 目前的证据对于因果关系仍然是不确定的.
- 需要进一步的前性研究来澄清这种关联,并为查策略提供信息.
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