美国前列腺癌老年男性的激素治疗模式,2010-2019年
Mohanad Albayyaa1, Yong-Fang Kuo2, Vahakn Shahinian3
1Department of Cardiovascular Medicine, John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Cancers
|October 16, 2025
概括
激素治疗 (HT) 的使用在高风险前列腺癌 (PCa) 中增加,但在低风险PCa中保持稳定,表明潜在的过度使用. 这一趋势凸显了对老年男性优化治疗策略的需求.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
背景情况:
- 激素疗法 (HT) 是前列腺癌 (PCa) 的关键治疗方法,特别是在患有晚期疾病的老年男性中.
- 了解HT使用的趋势对于优化治疗策略和改善患者治疗结果至关重要.
- 以前的研究集中在特定的患者亚组,需要对HT趋势进行更广泛的分析.
研究的目的:
- 为了评估随着时间的推移,在被诊断患有局部晚期和转移性前列腺癌的美国老年男性中,辅助和初级HT使用模式的变化.
- 分析HT给高风险和低风险PCa患者的管理趋势.
- 为了确定用于前列腺癌管理的HT利用的改进领域.
主要方法:
- 一项使用SEER-Medicare数据的队列研究 (149,515名年龄≥66岁的男性被诊断患有PCa,2010-2019).
- 对较高风险PCa的辅助HT和较低风险PCa的初级HT趋势的分析.
- 根据临床和人口因素调整的多变量后勤回归模型.
主要成果:
- 在高风险的PCa中,辅助性HT使用显著增加,从53.6% (2010) 增加到68.1% (2019).
- 在较低风险的PCa中,初级HT使用显示下降,然后从2017-2019年稳定在25-27.3%左右.
- 整体HT使用率从33.5% (2010) 增加到45.2% (2019),在调整后仍然存在.
结论:
- 增加辅助性HT符合指导方针,但在低风险PCa中稳定的初级HT表明使用不当.
- 研究结果强调,需要优化治疗选择和策略,以减少不必要的HT.
- 未来的研究应该专注于改进HT的管理,并减少不适当的初级HT在前列腺癌治疗中的使用.
相关概念视频
01:28Menopause
3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
01:20Disorders of the Male Reproductive System
4.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
4.0K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
01:15Drug Dosing: Geriatric Patients
222
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
222
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K