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针对蛋和牛奶过敏的益生菌口服免疫疗法诱导了持续的不反应
Melanie Lloyd1,2, Paxton Loke1,3,4, Kathy Nguyen1
1Allergy Immunology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
概括
使用益生菌的高剂量口服免疫疗法 (OIT) 显示出治疗儿童蛋和牛奶过敏的前景,可能导致持续不响应 (SU). 需要进一步的试验来确认安全性和有效性.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 使用益生菌的口服免疫疗法 (OIT) 对花生过敏有效,但其用于其他食物过敏的用途尚未确立.
- 这项研究调查了儿童高剂量蛋和牛奶OIT与益生菌的安全性和耐受性.
研究的目的:
- 评估高剂量快速升级OIT与益生菌在患有蛋或牛奶过敏的儿童的安全性和耐受性.
- 评估参与者实现持续不响应 (SU) 和改善生活质量的比例.
主要方法:
- 一项涉及40名 (5-17岁) 确诊患有蛋 (n=20) 或牛奶 (n=20) 过敏的儿童的开放性研究.
- 参与者接受了18个月的OIT与益生菌,通过双盲安慰剂控制食品挑战 (DBPCFC) 评估SU.
- 主要结局:遵守剂量升级;次要结局:SU,不良事件 (AE) 和与健康有关的生活质量 (HRQL).
主要成果:
- 45%的蛋和35%的牛奶参与者完成了剂量升级;85%达到修改后的维持阶段.
- 持续不响应 (SU) 达到55%的卵子过敏和50%的牛奶过敏.
- 经常发生中度/严重的与治疗相关的副作用 (45%蛋,65%牛奶),以及临床上显著的HRQL改善.
结论:
- 使用益生菌的高剂量快速升级OIT是一种对儿科蛋和牛奶过敏的有希望的方法.
- 这种治疗可能会增加SU的可能性,并可能缩短治疗时间.
- 需要进一步的安慰剂对照随机试验来确认疗效和安全性.
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