检测FGFR变化的反射体检测尿路癌:一个双机构的经验
Ngoc-Nhu Jennifer Nguyen1,2, Ekaterina Olkhov-Mitsel2, Kenneth J Craddock1,2
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
American journal of clinical pathology
|October 16, 2025
概括
在16.1%的尿路癌症中检测到FGFR变化,在上道瘤和肺转移中更高的患病率. 这些发现凸显了FGFR测试在晚期泌尿腺癌中的重要性.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 纤维细胞生长因子受体 (FGFR) 的改变与各种癌症有关.
- 尿路癌 (UTCs) 代表了一组多样化的恶性瘤,具有不同的遗传驱动因素.
- 识别可操作的突变,如FGFR变异,对于向治疗选择至关重要.
研究的目的:
- 为了确定FGFR变化的流行率 (FGFR1-4) 在尿路癌症的现实世界队列.
- 调查FGFR改变的UTCs的临床病理学关联.
- 评估反射下一代测序 (NGS) 在检测FGFR变化的有用性.
主要方法:
- 未来的下一代测序 (NGS) 使用在线综合测试 (OCA) v3 DNA和OCA Plus RNA在366 UTCs进行.
- 在2021年至2025年期间,在两个三级护理中心进行了测试.
- 反射测试适用于转移性和/或晚期 (pT3/4) 癌症.
主要成果:
- 在16.1% (59/366) 的UTC时段中发现了FGFR变化.
- 在13.4% (49/366) 的患者中发现了可操作的FGFR变化 (突变/融合).
- 在上道癌 (23.8%) 和下道癌 (13.8%) 和肺转移 (57.1%) 与其他转移部位 (10.4%) 相比,可操作的FGFR变化的患病率显著更高.
结论:
- 这项研究报告了FGFR1-4改变在尿路癌的双机构队列中的检测率.
- 在相当多的UTC中存在FGFR变化,特别是在上路瘤和转移中.
- 这些发现支持将反射FGFR测试纳入高级UTC管理中.
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