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微环境响应Cu-MOF纳米平台激活了迪苏尔菲拉姆,用于协同杀死细菌和增强受感染的伤口愈合

Yi Liu^1,2, Xujie Cui³, Minhao Guo³

¹National Key Laboratory of Agricultural Microbiology, College of Chemistry, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

Advanced healthcare materials

|October 16, 2025

概括

这项研究介绍了一种新的纳米平台,该纳米平台重新利用二硫 (DSF) 来对抗耐药细菌. 该平台在现场将无毒的DSF转化为有毒的形式,增强抗菌效果并促进伤口愈合.

科学领域:

纳米技术纳米技术
抗微生物耐药性抗微生物耐药性
药物重用药物重用

背景情况:

耐药性细菌感染是一个关键的全球卫生挑战.
迫切需要开发新的抗微生物药物.
重新利用现有药物提供了一种可行的策略来打击耐药性.

研究的目的:

开发一个响应的纳米抗菌平台 (DSF@HKUST-1@Dex) 用于治疗耐药性感染.
调查在感染微环境中的二硫 (DSF) 在现场转化为有毒的形式.
评估非催化处理和铜离子诱导的细菌死亡的协同抗菌效应.

主要方法:

一个纳米抗菌平台的制造 (DSF@HKUST-1@Dex).
在轻度酸性条件下对DSF激活和铜离子结合的研究.
在细菌伤口感染模型中评估抗菌活性.
蛋白质组分析以阐明作用机制.

主要成果:

纳米平台有效释放二硫 (DSF),它在现场变得有毒.
铜离子破坏细菌的新陈代谢,抑制三碳酸 (TCA) 循环,并诱导类似cuproptosis的死亡.
该平台表现出显著的抗菌活性,促进了伤口愈合,减少了炎症.
蛋白质组分析揭示了细菌细胞壁和能量代谢的破坏.

结论:

开发的纳米平台为治疗耐药性感染提供了一个有前途的战略.
通过现场转换重新利用二硫是一种新的抗微生物方法.
该平台有效地准细菌结构和代谢途径,抑制其生长.

关键词:

细菌的cuproptosis-like死亡的死亡.药物重用是为了改变药物的用途.耐药细菌是一种耐药细菌.金属有机的框架.刺激响应交付平台提供刺激响应平台.

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