产后早期感染人类细胞巨化病毒对以前过早出生儿童的大脑结构有长期影响
Meike Müller1,2, Karen Lidzba3, Christian Gaser4,5,6
1Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital Tübingen, Tübingen, Germany.
Brain and behavior
|October 16, 2025
概括
在早产婴儿的早期产后人类细胞巨乳病毒 (hCMV) 感染可能导致明显的长期大脑结构变化,不同于单独早产的影响. 这些发现强调了在脆弱的早产人群中预防hCMV的重要性.
科学领域:
- 神经科学是一个神经科学.
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
背景情况:
- 人类先天性细胞巨乳病毒 (hCMV) 导致严重的神经发育问题.
- 孕期婴儿的产后hCMV感染通常没有不良后果.
- 尽管有可用的预防措施,早产后hCMV对早产婴儿的长期影响仍在争论中.
研究的目的:
- 研究早期产后hCMV感染对早产儿大脑结构的长期后果.
- 区分早产和hCMV感染对大脑发育的影响.
主要方法:
- 分析了37名早产婴儿 (孕期≤32周和/或≤1500g) 的脑成像数据,其中包括14名早产后hCMV感染者 (PT hCMV+) 和23名没有 (PT hCMV-).
- 与38名健康的按期出生的婴儿进行了比较.
- 评估全球和本地组织体积和大脑表面参数,分析早产 (FT与PT) 和hCMV感染 (PT hCMV-与PT hCMV+) 的影响.
主要成果:
- 过早出生的婴儿 (PT) 与过期出生的婴儿 (FT) 相比,具有较低的全球灰质 (GM) 量.
- 与PT hCMV-婴儿相比,PT hCMV+婴儿的全球GM趋势更高.
- 虽然早产影响了局部转基因体积和皮质厚度 (主要是右半球),但早产婴儿的hCMV感染与皮质厚度意外广泛增加有关,这表明皮质厚度的双边前部增加具有持久的影响.
结论:
- 过早生育与全球和本地灰色物质量减少有关.
- 在早产婴儿的早期产后hCMV感染导致长期的大脑结构变化,与仅由早产引起的不同.
- 这些发现强调,需要实施预防早产婴儿hCMV感染的策略,以减轻潜在的不良神经发育后果.
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