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纳米运动促进的现场疫苗接种对于深层癌症免疫疗法

Anjun Song^1,2, Heying Yuan^1,2, Wenjie Wang^1,2

¹State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. China.

|October 16, 2025

概括

这项研究引入了用于深层癌症免疫治疗的纳米电机,通过改善药物透和通过免疫细胞死亡诱导激活抗瘤免疫反应来增强局部瘤疫苗接种.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症免疫疗法免疫疗法

背景情况:

通过免疫细胞死亡 (ICD) 在位瘤接种疫苗对癌症免疫疗法有希望.
药物透率有限和瘤免疫抑制阻碍了当前的策略.
开发有效传递和免疫激活的方法至关重要.

研究的目的:

开发一种基于纳米运动的策略,用于深层癌症免疫治疗.
通过改善细胞外基质透和免疫调节来增强现场疫苗接种.
研究纳米电机在激活抗瘤免疫反应方面的潜力.

主要方法:

制造一个纳米电机 (AHC-电机) 使用与酶结合的,素键修饰的空心等性二氧化封装5-阿米诺氨酸.
利用纳米电机在H2O2中的活跃运动,以加强对深层瘤组织的透.
评估免疫细胞死亡 (ICD) 的纳米运动介导诱导和干扰素基因刺激器 (STING) 途径的激活.
评估纳米电机促进指蛋白质持续硫化和细胞因子释放的能力.

主要成果:

AHC-纳米发动机证明了有效地透到深层瘤组织中,增加了细胞吸收ICD诱导器.
我们成功地制造了现场疫苗,并激活了STING通路.
纳米发动机促进了指蛋白质的再硫化,导致炎症性细胞因子释放的增加.
纳米运动策略增强了in situ疫苗治疗的疗效.

结论:

开发的纳米电机通过克服透障碍,促进了深层癌症免疫疗法.
这种策略有效诱导免疫细胞死亡,并调节瘤微环境.
纳米发动机为先进的in situ瘤疫苗接种和免疫疗法开发提供了一个有前途的平台.

关键词:

刺痛是一种刺痛.免疫疗法免疫疗法在本地疫苗疫苗.纳米引擎是一个纳米引擎.继续硫化继续硫化继续硫化指蛋白质是一种指蛋白质.

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