[喘儿童的肠道微生物组,代谢组和基因素H4乙化之间的多omics关联]
Ping Zheng1, Chuanchuan Yu1, Xifang Lyu1
1National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Wei sheng yan jiu = Journal of hygiene research
|October 16, 2025
概括
肠道微生物群通过通过特定代谢物改变基因素H4乙化水平来影响儿童喘. 这种表观遗传变异提供了一个潜在的机制,将肠道细菌与儿童喘发展联系起来.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 微生物组研究的研究.
- 儿科喘 儿科喘 儿童喘
背景情况:
- 儿童喘是一种复杂的呼吸系统疾病,具有多因素的原因.
- 肠道微生物组在免疫系统发育中的作用及其对喘的潜在影响是目前正在积极研究的领域.
- 表观遗传修饰,如基因组乙化,越来越多地被认为是疾病发病的关键媒介.
研究的目的:
- 调查喘儿童肠道微生物组,代谢组和基因素H4乙化水平之间的相关性.
- 通过表观遗传调节阐明肠道微生物群通过表观遗传调节影响儿童喘的机制.
主要方法:
- 收集的诱导唾液用于组织素H4乙化分析和便样本用于16SrRNA基因测序 (肠道微生物组) 和非向代谢.
- 采用网络分析来确定喘相关的肠道微生物与素H4乙化之间的相关性.
- 利用量子G计算 (QGC) 和调解模型来评估肠道微生物和代谢物对素H4乙化的影响.
主要成果:
- 与对照人群相比,喘儿童表现出明显的肠道微生物特征和改变的素H4乙化水平.
- 五种特征性肠道属与基因素H4乙化有显著的相关性,对其水平产生积极影响.
- 确定了34种便代谢物与肠道微生物和组织素H4乙化显著相关,Prevotella通过特定代谢物影响乙化.
结论:
- 与喘儿童特征性肠道细菌相关的代谢物与素H4乙化有关.
- 这些发现表明,肠道微生物组可能通过调节表观遗传变异,特别是基因素乙化来诱导儿童喘.
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