临床试验:利法西明与低FODMAP饮食对抗刺激性肠综合征
Kee Huat Chuah1, Qing Yuan Loo1, Audrey Joe Chii Loh1
1Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Alimentary pharmacology & therapeutics
|October 16, 2025
概括
利法西明和低FODMAP饮食 (LFD) 在四周内对刺激性肠综合征 (IBS) 症状的缓解提供了可比的疗效. 然而,利法西明可以提供更快的症状改善和更好的治疗坚持.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 药理学 药理学是指药理学的学科.
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的胃肠疾病.
- 利法西明和低FODMAP饮食 (LFD) 是IBS的第二线治疗方法.
- 对于这两种疗法,有有限的直接比较数据.
研究的目的:
- 为了比较RIFAXIMIN与LFD在IBS患者中的疗效.
- 评估症状改善,生活质量和细菌过度生长.
- 评估治疗坚持性和安全概况.
主要方法:
- 进行了一项单盲,随机对照试验.
- 100名IBS成年人被分配给接受利法西明或LFD.
- 主要结局:第4周综合症状改善. 二次结局:个体症状,IBS-SSS,HRQOL,焦虑,SIBO根除,坚持和不良事件.
主要成果:
- 在第4周,反应率相似 (利法西明56.0%与LFD48.0%).
- 利法西明在第二周之前显著提前改善了整体症状,胀气和腹痛.
- 与利法西明 (95.9%与77.8%相比) 观察到更高的坚持. 瑞法西明的SIBO根除率为63.6%,LFD的SIBO根除率为50.0%.
结论:
- 利法西明和LFD在4周的时间内在治疗IBS症状方面表现出相似的疗效.
- 利法西明提供了更快缓解症状和改善治疗坚持的优势.
- 利法西明为有效的IBS症状管理提供了切实可行的替代方案.
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