稳定状态乳酸脱酶水平与状细胞并发症之间的关联:系统性审查
Sagad O O Mohamed1, Amged Mohammed2, Fatima S K Salih1
1Department of pediatrics and child health, University of Khartoum, Khartoum, Sudan.
Avicenna journal of medicine
|October 16, 2025
概括
在状细胞病 (SCD) 稳定状态期间乳酸脱酶 (LDH) 水平升高与严重并发症有关. 这一发现表明,LDH是预测SCD严重程度和指导患者护理的有价值生物标志物.
科学领域:
- 血液学 血液学 血液学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 状细胞疾病 (SCD) 是一种严重的遗传性血液疾病,具有严重的并发症.
- 确定可靠的SCD严重性生物标志物至关重要,特别是在资源有限的环境中.
- 乳酸脱酶 (LDH) 是SCD并发症的潜在生物标志物.
研究的目的:
- 系统地审查稳定状态LDH水平与SCD并发症之间的关联.
- 评估LDH在预测SCD严重性的预后价值.
- 评估LDH作为SCD患者风险分层的具有成本效益的生物标志物.
主要方法:
- 在主要数据库 (Medline/PubMed,Web of Science,Embase,ScienceDirect) 进行系统的文献搜索,遵循PRISMA指南.
- 包括34项观察性研究,检查LDH水平和随后的SCD并发症.
- 使用标准化平均差异 (SMD) 和95%置信区间 (CI) 的统计分析来汇集结果.
主要成果:
- 升高的稳定状态LDH水平与肺动脉高血压有显著的关联 (SMD=0.454,p=0.035).
- 较高的LDH水平与中风风险增加相关,通过横多普勒检测确定 (SMD=0.651,p<0.001).
- 在升高的LDH和脏干扰之间发现了显著的关联 (SMD=0.399,p=0.042).
结论:
- 稳定状态LDH升高与SCD主要并发症之间存在一致的关联.
- LDH显示出作为SCD严重程度的随时可用的生物标志物的潜力.
- 这些发现支持将LDH纳入临床评估中的风险分层和SCD定制干预措施.
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