Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

674
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
674
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.1K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Stratified polymer brushes from microcontact printing of polydopamine initiator on polymer brush surfaces.

Macromolecular rapid communications·2014
Same author

Distinct morphological features of ruptured culprit plaque for acute coronary events compared to those with silent rupture and thin-cap fibroatheroma: a combined optical coherence tomography and intravascular ultrasound study.

Journal of the American College of Cardiology·2014
Same author

The ABI4-induced Arabidopsis ANAC060 transcription factor attenuates ABA signaling and renders seedlings sugar insensitive when present in the nucleus.

PLoS genetics·2014
Same author

Evaluation of global longitudinal strain of left ventricle and regional longitudinal strain in the region of left ventricular leads predicts the response to cardiac resynchronization therapy in patients with ischemic heart failure.

Cell biochemistry and biophysics·2014
Same author

Exosomes derived from mesenchymal stem cells.

International journal of molecular sciences·2014
Same author

Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult.

Lipids in health and disease·2014

相关实验视频

Updated: Jan 15, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

26.2K

最近在牛皮中DNA甲基化方面的进展.

Zhaoping Lin1,2,3, Xiaoting Wu4,5, Xuqin Hong6

  • 1Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Frontiers in genetics
|October 16, 2025
PubMed
概括

表观遗传学,特别是DNA甲基化 (DNAm),在了解牛皮方面越来越重要. 研究强调DNAm变化是牛皮发育的关键因素和潜在的治疗点.

关键词:
通过DNA甲基化.表观遗传学是指表观遗传学.病变的发生和发病.在进步方面取得了进展.牛皮是一种牛皮.

更多相关视频

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.2K
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

10.3K

相关实验视频

Last Updated: Jan 15, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

26.2K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.2K
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

10.3K

科学领域:

  • 皮肤病学和免疫学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 分子生物学分子生物学

背景情况:

  • 牛皮是一种由遗传,免疫和环境因素影响的慢性炎症性皮肤病.
  • 表观遗传学,即在不改变DNA序列的情况下基因表达的遗传性变化,是牛皮的快速发展的研究领域.
  • 基因甲基化 (DNAm) 是最常见的表观遗传机制,并且得到了广泛的研究.

研究的目的:

  • 综述和总结最近在了解牛皮病发病过程中的DNA甲基化方面的进展.
  • 突出DNAm改变在牛皮的发展中的作用.
  • 根据DNAm.确定牛皮的潜在治疗点.

主要方法:

  • 关于DNA甲基化和牛皮的最近研究的文献综述.
  • 对专注于牛皮病变中的表观遗传修饰的研究进行分析.
  • 在牛皮中不同甲基化部位的发现的综合.

主要成果:

  • DNA甲基化在牛皮的发病过程中起着重要作用.
  • 在患有牛皮的个体中观察到异常的DNAm模式.
  • 特定的不同甲基化部位显示出作为治疗点的潜力.

结论:

  • DNA甲基化是牛皮发育的关键因素.
  • 向DNAm改变为牛皮提供了有前途的治疗策略.
  • 对表观遗传机制的持续研究对于推进牛皮治疗至关重要.