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Updated: Jan 15, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
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Published on: November 27, 2019

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RAC1作为急性肝衰竭的新型治疗点

Barbara Bueloni1,2,3, Esteban Fiore1,2,4, María José Cantero1,2,4

  • 1Hepatology and Gene Therapy Program, Instituto de Investigaciones en Medicina Traslacional, CONICET - Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina.

JHEP reports : innovation in hepatology
|October 16, 2025
PubMed
概括

用1D-142准RAC1 (Rho GTPase) 蛋白质有效地减少了急性肝衰竭 (ALF) 模型中的肝损伤,炎症和氧化应激. 这表明RAC1抑制是ALF的有前途的治疗策略.

关键词:
自体免疫性肝炎是一种自身免疫性肝炎.药物诱导的肝损伤是药物诱导的肝损伤.与HBV相关的肝衰竭肝细胞的亡是肝细胞的亡.巨细胞的两极分化分子抑制剂 分子抑制剂在RHO GTPases中使用.

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