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来自蜜蜂蜂巢的内性Streptomyces抑制了植物和蜜蜂病原体

Claire Reichardt¹, David Estes², Caitlin M Carlson¹

¹Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States.

Frontiers in microbiology

|October 16, 2025

概括

蜜蜂面临害虫和疾病的威胁,需要新的治疗方法. 来自花粉和蜂巢的活性菌产生天然产品,显示出保护这些重要授粉者的潜力.

科学领域:

微生物学微生物学
生态生态学生态生态学
生物技术是生物技术.

背景情况:

蜜蜂是全球重要的作物授粉者,但由于暴露在农药和易受疾病的影响,它们的数量正在下降.
蜜蜂疾病的现有治疗方法存在局限性,包括安全性差,病原体耐药性增加.
研究正在探索从与蜜蜂相关的动因细菌中获得的天然产品,以进行新的蜂巢治疗,但它们的环境起源需要进行调查.

研究的目的:

为了研究从植物和蜂巢花粉储存中分离出来的动态细菌.
确定孤立的Streptomyces菌株的遗传学关系和生物合成潜力.
评估这些动态细菌及其产品对植物和蜜蜂病原体的抗微生物活性.

主要方法:

从花粉和蜂巢样本中分离和表征动态细菌.
精选的Streptomyces菌株的全基因组测序.
遗传学分析,内生植物标记物的鉴定,以及生物合成基因集群的比较.
液体染色学-双重质谱学 (LC-MS/MS) 用于天然产品的确认.
在实验室中测试病原体抑制的行为细菌.

主要成果:

从植物和蜂巢环境中分离出来的Streptomyces菌株与内菌株具有共同的特征.
基因组分析揭示了家族遗传关系,并确定了内植物主义的遗传标记.
通过选定的菌株确认生产天然产品,包括来自Streptomyces albidoflavus和Streptomyces olivaceus的菌株.
孤立的动因细菌显示出对植物和蜜蜂病原体的抑制作用.

结论:

动态细菌,特别是Streptomyces物种,如S. albidoflavus和S. olivaceus,在植物和蜂巢环境中都存在.
这些微生物生产的天然产品具有潜在的应用作为新型抗生素蜂蜜健康.
这项研究为开发新疗法来保护授粉者提供了基础.

关键词:

蜜蜂鸟 (Apis mellifera) 是一个有趣的动物.它们的幼虫Paenibacillus.这种病名为Streptomyces.行动类细菌 (actinobacteria) 是一种细菌.它们的内基质 (endophyte) 是:自然产品是自然产品的产品.二次代谢产物二次代谢产物

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