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石榴皮中的多可以通过调节通过Notch/NF-κB信号通路的炎症来保护

Yun Wang^1,2, Mingfang Zhu¹, Shuhui Wu¹

¹Department of Dermatology, the Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China.

Journal of inflammation research

|October 16, 2025

概括

石榴皮聚醇 (PPPs) 通过抑制Notch/NF-κB通路来减少. 这种天然化合物有效降低炎症因素和巨细胞的表达,为普通提供了有前途的治疗方法.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

石榴皮的多 (PPPs) 在中国传统医学中用于治疗.
在治疗 (AV) 中PPP的确切机制尚不清楚.
由Notch信号和NF-κB激活调节的炎症反应是AV病变发生的核心.

研究的目的:

调查PPP在治疗的潜在机制.
阐明PPPs在模型中调节Notch/NF-κB信号通路中的作用.

主要方法:

在SD大鼠中建立了一个体内模型,使用Cutibacterium acnes (C. acnes) 注射.
在实验室中,RAW264.7细胞用脂多糖 (LPS) 刺激.
评估了PPP对炎症因子和Notch/NF-κB信号通路的影响.

主要成果:

在C. acnes诱导的老鼠中,PPPs治疗降低了炎症因子 (IL-1α,TNF-α,IL-6,IL-8,IL-12) 的血清和皮肤病变水平.
在皮肤病变中,PPPs降低了巨细胞的表达.
观察到诺奇,NF-κB蛋白和mRNA表达的抑制,以及NF-κB酸化.

结论:

PPP通过抑制Notch/NF-κB信号通路来表现出抗的作用.
PPP有效地减少与相关的炎症反应.
这项研究强调了PPP作为一种潜在的治疗的治疗剂.

关键词:

这是Notch/NF-κB信号通路.一般性 (acne vulgaris) 是一种炎症,RAW264.7 细胞的使用.石榴皮中的多,多.

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