睡眠行为改变了血红蛋白度和呼吸道感染之间的关联:一个潜在的队列分析
Yongkui Zhu1, Qian Chen1, Mengying Wang2,3
1Department of Intensive Care Unit, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, China.
Frontiers in physiology
|October 16, 2025
概括
血红蛋白 (Hb) 水平和呼吸道感染风险显示出一个U形的关联,受睡眠时间型的影响. 较高的Hb水平会增加感染风险,尤其是在晚期时代型的人群中.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠科学 睡眠科学
- 血液学 血液学 血液学
背景情况:
- 血红蛋白 (Hb) 水平对于氧气运输至关重要,但它们与呼吸道感染风险的关联是复杂的.
- 睡眠行为,包括时间型,越来越多地被认为是健康结果的调节者.
- 了解Hb,睡眠和呼吸系统健康之间的相互作用对于公共健康至关重要.
研究的目的:
- 研究血红蛋白水平与住院呼吸道感染的发生率之间的非线性关系.
- 探索睡眠行为,特别是时间型,如何改变这种关联.
主要方法:
- 使用英国生物银行进行的一项大型队列研究,包括292,568名没有先前呼吸系统疾病,癌症或贫血的参与者.
- 在基线测量了血红蛋白水平,参与者在平均12.6年内对发生的呼吸道感染进行了跟踪.
- 统计分析检查了Hb和呼吸道感染之间的非线性关联,并测试了与睡眠行为 (如时间型) 的相互作用.
主要成果:
- 在男性和女性之间观察到Hb水平和呼吸道感染风险之间存在显著的U形关联.
- 在男性Hb水平高于15.0g/dL,女性Hb水平高于13.5g/dL时,风险增加.
- 发现Hb度与时型之间存在显著的相互作用 (P=0.005),较高的Hb度在晚期时型的个体中构成更大的风险.
结论:
- 血红蛋白水平和呼吸道感染风险呈现出非线性,U形的关系.
- 时型显著改变了这种关联,表明晚期时型的个体更容易受到更高Hb水平的呼吸道感染.
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