在接受前列腺SBRT与前列腺内增强治疗的患者中,尿路生活质量
Nisha Bhargava1, Martina Hurwitz2, Josephine Levey1
1Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Frontiers in oncology
|October 16, 2025
概括
在前列腺癌中,静态体辐射疗法 (SBRT) 与前列腺内增强 (IPB) 耐受性良好,显示出可接受的尿路生活质量变化. 膀剂量差异与患者报告的结果相关.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 立体放射疗法 (SBRT) 是局部性前列腺癌的标准治疗方法.
- 在SBRT中,全腺剂量升级仍然是争论的主题.
- 同时的前列腺内增强 (IPB) 是剂量升级的潜在策略.
研究的目的:
- 为了评估国际前列腺症状评分 (IPSS) 在SBRT与IPB后12个月的变化.
- 为了比较经历了最小重要的差异 (MID) 和没有经历的患者之间的尿路生活质量指标.
- 为了确定与患者报告的结果相关的潜在剂量测量差异.
主要方法:
- 包括74名接受SBRT与IPB的患者.
- IPSS在治疗前,治疗后3个月和12个月的随访时间被评估.
- 患者根据在IPSS中经历MID而分层;尿道和膀剂量在队列之间进行了比较.
主要成果:
- 62%的患者在他们的IPSS得分中经历了MID.
- 中位数IPSS在治疗后出现波动,在MID队列中12个月后有改善的趋势.
- 在患有MID和没有MID的患者之间,在最大膀剂量 (D0.03cc) 中观察到统计学上显著的差异 (41.9 Gy vs 40.2 Gy,p < 0.001).
结论:
- 带有IPB的SBRT耐受性良好,尿路生活质量有可接受的变化.
- 最大膀剂量是根据患者的尿路生活质量结果区分患者的一个重要因素.
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