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Updated: Jan 15, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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保存的MHC I类细胞质氨酸的突变会影响CD8+ T细胞的原始化,效应器功能和记忆反应

Yimo Sun1,2, Yitao Tang1,3, Priscilla Ortiz2

  • 1UT Health Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Frontiers in immunology
|October 16, 2025
PubMed
概括

在MHC I类分子上改变特定的氨酸残留物 (Y320) 会增强T细胞的反应. 这一发现为改善树突细胞 (DC) 癌症免疫疗法提供了新的策略.

关键词:
在MHC I类中,MHC是I类.细胞质尾巴细胞质尾巴细胞毒性T细胞树突细胞是一种树突细胞.人类白细胞抗原 (HLA)铁酸酸化的铁酸.

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