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乙烯氧化物暴露与中年和年轻成年人骨关节炎风险之间的关联:一个横截面研究

Xudong Wang¹, Meng Wang², Zijian Guo¹

¹Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Frontiers in public health

|October 16, 2025

概括

对乙烯氧化物 (EO) 的暴露与年轻和中年成人骨关节炎 (OA) 的风险更高有关. 更高的EO暴露显著增加了OA风险,需要进一步的调查和管理策略.

科学领域:

环境健康环境健康
类风湿病学类风湿病学
流行病学流行病学

背景情况:

乙烯氧化物 (EO) 暴露与骨关节炎 (OA) 风险之间的联系尚未得到充分证实.
这项研究调查了EO暴露和OA在年轻和中年成年人之间的关联.

研究的目的:

探索乙烯氧化物 (EO) 暴露与患骨关节炎 (OA) 的风险之间的关联.
根据EO暴露和其他因素,开发OA风险的预测模型.

主要方法:

分析了来自2013-2018年国家健康和营养检查调查的2,380名成年人 (20-60岁) 的数据.
使用权重多变量回归,平滑曲线拟合,子组分析和相互作用测试来评估EO暴露和OA风险.
使用变量选择技术 (LASSO和多变量回归) 构建了一个预测模型.

主要成果:

增加的乙烯氧化物 (EO) 暴露与更高的骨关节炎 (OA) 风险显著相关.
与最低三分之一 (p-趋势=0.002) 相比,EO暴露的最高三分之一的个体显示OA风险增加了224% (OR=3.24).
在子组分析中没有发现非线性关联或显著相互作用. 开发了一个具有良好的区分能力的预测模型.

结论:

乙烯氧化物 (EO) 暴露与年轻和中年成人骨关节炎 (OA) 风险有关.
结合EO暴露的新型预测模型可以帮助评估和管理高风险的OA个体.

关键词:

跨截面研究是跨截面研究.乙烯氧化物乙烯氧化物中年和年轻的成年人.国家健康和营养检查调查调查骨关节炎是一种关节炎.

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