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Updated: Jan 15, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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E3 无处不在的酶 Trip12 半选择性地减弱了 Wnt 信号传递

Jessica Ensing1, Amber D Ide1, Carla Gilliland1

  • 1Department of Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.

iScience
|October 16, 2025
PubMed
概括

这种E3泛基因酶Trip12针对Frizzled 9b (Fzd9b),促进其降解并抑制Wnt9a/Fzd9b信号传输. 这种受体特异性调节会影响造血干细胞的增殖.

关键词:
生物化学 生物化学细胞生物学 细胞生物学

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