与不同类型的腐蚀抑制剂相关的抗生素耐药性变化 当作为消毒剂使用时
Lee K Kimbell1, Numair Ali2, Maya Adelgren1
1Dept of Civil, Construction and Environmental Engineering, Marquette University, Milwaukee, Wisconsin 53233, United States.
概括
饮用水系统中的腐蚀抑制剂在与相结合时可以增加抗生素耐药的细菌. 酸盐基抑制剂特别增强了对安皮西林的耐药性,突出了管理抗生素耐药性基因 (ARG) 需要仔细选择的必要性.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 饮用水系统使用用于消毒和腐蚀抑制剂,以防止金属出.
- 和各种腐蚀抑制剂对抗生素耐药性的联合影响尚不清楚.
- 腐蚀抑制剂对于保持水质和基础设施完整性至关重要.
研究的目的:
- 研究三种常见的腐蚀抑制剂 (正酸盐,正酸盐,酸盐) 与一起使用时如何影响抗生素耐药性.
- 确定不同腐蚀抑制剂对抗生素耐药细菌和基因 (ARG) 的丰富性和类型的影响.
主要方法:
- 使用实验室规模的微观宇宙来模拟饮用水分配系统.
- 基于培养的涂层评估了耐抗生素的细菌种群.
- 甲基因组学分析确定了特定的抗生素耐药性基因 (ARG) 和它们的位置 (染色体,等离子体,整体).
主要成果:
- 所有测试的腐蚀抑制剂都显著增加了对利芬素,硫甲醇和万科迈素耐药的细菌的丰富性.
- 基抑制剂 (正酸盐,正酸盐) 进一步增加了对安皮西林的耐药性.
- 暴露于抑制剂和增加了与多药物和抗性相关的ARG,在等离子体和整体体上发现了更多的ARG.
结论:
- 选择腐蚀抑制剂显著影响饮用水系统中抗生素耐药性的发展.
- 基于酸盐的抑制剂可能会增加促进特定抗生素耐药性的风险.
- 了解这些相互作用对于制定减轻饮用水中抗生素耐药性的策略至关重要.
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