在三阴性乳腺癌中,FOXP3表达和无疾病生存之间的关联
Himawan Adhitama1, Suwardjo Suwardjo1, Ery Kus Dwianingsih2
1Department of Surgery, Surgical Oncology Division, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Iranian journal of pathology
|October 16, 2025
概括
在三阴性乳腺癌 (TNBC) 中高FOXP3表达与较差的无病生存率 (DFS) 相相关. 这一发现为TNBC预后和潜在的治疗点提供了洞察力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有攻击性亚型,由于复发率高和转移,预后不佳.
- FOXP3表达与抑制的抗瘤免疫有关,是TNBC的潜在预后标志物.
- 在TNBC中FOXP3表达的预后意义,特别是关于无病生存 (DFS) 的预后意义,仍在争论中.
研究的目的:
- 在TNBC患者中调查FOXP3表达和DFS之间的关联.
- 为了澄清FOXP3在这种侵袭性乳腺癌亚型中的预后价值.
主要方法:
- 一项对47名TNBC患者的回顾性研究.
- 免疫组织化学被用来评估FOXP3的表达,分为低或高.
- 进行了单变量和多变量考克斯回归分析和卡普兰-梅尔生存分析.
主要成果:
- 高FOXP3表达显着与更糟糕的DFS相关 (p=0.019).
- 更高的癌症阶段也与更糟糕的DFS显著相关 (p=0.002).
- 在FOXP3表达和年龄,瘤大小,淋巴结状况,瘤等级,淋巴血管入侵 (LVI) 或瘤透淋巴细胞 (TIL) 之间没有发现显著的关联.
结论:
- 高FOXP3表达是TNBC患者较低DFS的重要指标.
- 在TNBC中,FOXP3表达似乎与常见的临床病理因素无关.
- 这些发现突出了FOXP3作为TNBC的潜在预后生物标志物.
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