未成熟粒细胞在预测复杂尾炎中的作用:一项回顾性观察性研究
Mehmet Akif Üstüner1, Oğuzhan Fatih Ay2, Ali Vuslat Özen3
1Department of Gastroenterologic Surgery, Bursa Faculty of Medicine, University of Health Sciences, Bursa City Hospital, 16110 Bursa, Turkiye.
Annali italiani di chirurgia
|October 16, 2025
概括
在初步分析中,不成熟颗粒细胞计数 (IG#) 和百分比 (IG%) 显示与复杂尾炎 (CA) 有关,但不是独立的预测因素. 需要进一步的研究来澄清它们在诊断CA.的临床实用性.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 手术病理学手术病理学
背景情况:
- 区分复杂尾炎 (CA) 和非复杂尾炎 (UA) 对于手术规划和患者的治疗结果至关重要.
- 未成熟颗粒细胞计数 (IG#) 和百分比 (IG%) 是易于获得的实验室参数.
- 在CA中IG#和IG%的诊断实用性需要进一步研究.
研究的目的:
- 评估不成熟颗粒细胞计数 (IG#) 和百分比 (IG%) 作为诊断复杂尾炎 (CA) 的潜在生物标志物的作用.
- 在UA和CA患者之间比较实验室参数,包括IG#和IG%.
主要方法:
- 对459名接受紧急尾切除手术的患者进行了回顾性观察性研究.
- 患者根据他的病理学 (CA定义为穿孔或炎) 被分为UA和CA组.
- 分析了实验室参数,包括IG#,IG%,C反应蛋白,白细胞计数和中性粒细胞与淋巴细胞的比率.
主要成果:
- 与UA患者相比,CA患者 (15.9%) 年龄较大,CRP,直接胆红素,WBC,IG#,IG%和NLR水平明显高于UA患者 (p < 0.001).
- 接收器操作特征分析显示IG# (AUROC = 0.699) 和IG% (AUROC = 0.663) 的诊断性能中等.
- 多变量分析表明,IG#和IG%不是CA的显著独立预测因素.
结论:
- 在单变量分析中,高的IG#和IG%水平与复杂的尾炎有关.
- 在多变量模型中,这些标记物并没有成为显著的独立预测因素.
- 需要进一步的前性研究来确定IG#和IG%在治疗尾炎中的确切临床作用.
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