遗传祖先与自我报告的种族/种族之间的复杂关系
Yambazi Banda1,2, Neil Risch2,3,4
1Spectrum Biobank, San Francisco, California, USA.
Genetic epidemiology
|October 16, 2025
概括
在生物医学研究中,自我报告的种族和种族往往与遗传祖先有所不同. 大多数混合个体都认同少数群体,除了美洲原住民,复杂的健康差异研究.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 社会学 社会学 社会学
背景情况:
- 种族和种族是生物医学研究中评估健康差异的关键人口结构.
- 它们作为社会或生物结构的分类以及与遗传祖先的关系受到争议.
- 目前的方法主要依赖于流行病学研究中自我报告的种族和种族.
研究的目的:
- 调查自我报告的种族/种族和遗传祖先之间的复杂关系.
- 分析大型队列中的自我报告模式,以了解与遗传数据的差异.
- 在生物医学和流行病学研究中对种族/种族类别的解释提供信息.
主要方法:
- 分析自报道的种族/种族和基因祖先数据从97,671个个体在凯泽永久性北加州遗传流行病学研究成人健康和衰老 (GERA) 队列.
- 使用43,988个单核酸多态 (SNP) 来从全基因组基因型阵列中确定遗传祖先.
- 统计检查自我认同的种族/种族群体和估计的遗传祖先比例之间的相关性.
主要成果:
- 作为非洲裔美国人,东亚人和拉丁裔的自我认同 (a) 随着相应的遗传祖先显著增加.
- 白人的身份认同只在欧洲/西亚血统显著上升,这表明混合个体经常采用少数民族身份.
- 美国原住民的自我认同显示出与欧洲祖先,而不是美国原住民祖先的惊人的正相关性.
结论:
- 遗传混合影响种族/种族自我认同,倾向于采用少数群体标签.
- 自我报告与遗传祖先之间的断开,特别是对于美洲原住民来说,对研究有重大影响.
- 研究结果强调,需要仔细考虑在健康差异研究中如何对种族和种族进行分类和解释.
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