针对阿尔茨海默病的疾病修饰药物:曲折曲线
Faheem Arshad1, Suvarna Alladi
1Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Annals of Indian Academy of Neurology
|October 16, 2025
概括
阿尔茨海默病的治疗方法正在进步,但由于昂贵的诊断生物标志物,在低收入国家获得治疗方法是有限的. 新的,负担得起的生物标志物和全球研究对于公平的阿尔茨海默病护理至关重要.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔茨海默病 (AD) 是全球老年人口中痴呆和残疾的主要原因.
- 最近对抗粉样蛋白单克隆抗体的批准为阿尔茨海默病提供了修改疾病的治疗方法.
- 这些治疗方法的临床可用性有限,特别是在低收入和中等收入国家 (LMICs),是一个重大挑战.
研究的目的:
- 审查目前用于阿尔茨海默病的疾病修饰药物,包括疗效和安全性.
- 检查在LMICs中对AD治疗的实施挑战.
- 探索新兴的治疗策略和AD治疗的未来方向.
主要方法:
- 批评审查已批准的阿尔茨海默病 (AD) 疗法.
- 分析诊断生物标志物 (CSF,PET成像) 的要求及其局限性.
- 探索超越粉样蛋白和蛋白标的新疗法.
主要成果:
- 已批准的AD疗法,主要是抗粉样蛋白抗体,由于高成本和依赖先进诊断而面临可访问性问题.
- 在资源有限的环境中,基于生物标志物 (CSF,PET) 的诊断通常是不可用或不可负担的.
- 新兴策略包括血交换,突触调节器和基于基因的方法.
结论:
- 迫切需要负担得起,可扩展的生物标志物用于早期AD诊断和干预,特别是在LMICs.
- 加强医疗保健系统和促进包容性研究对于全球平等获得AD治疗至关重要.
- 未来的AD疗法需要采用多方面的方法,包括治疗和诊断的可访问性.
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