重复眼内抽样和微生物检测在传染性内炎:在澳大利亚全州三级推中心进行27年的前性观察研究
Pravena Kumaran1,2, Maedbh Rhatigan1,3, Zelia Chiu1
1Vitreoretinal Unit, The Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Clinical & experimental ophthalmology
|October 16, 2025
概括
在内眼炎中重复采集眼睛样本可以改善诊断. 玻璃式水龙头提供了最高的初始产量,重复采样,特别是从水性或手术样本,可以识别最初错过的病原体.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 需要为微生物学测试取多个眼组织样本的内炎并不常见.
- 这项研究分析了至少有两个眼睛组织样本的病例,并对不同眼睛样本的测试与培养产量进行了测试.
研究的目的:
- 用至少两份眼部组织样本分析内眼炎病例.
- 评估不同眼睛样本的微生物培养产量,并重复采样.
主要方法:
- 这是一项长达27年的前性观察研究,使用了维多利亚州内眼炎登记处的数据.
- 包括314名患者 (317只眼睛),至少有两次水性或玻璃体样本采集.
- 主要结局:通过重复和多次眼内样本的微生物培养结果和孤立微生物的识别.
主要成果:
- 整体初始培养阳性率为75.7%;第二次干预阳性率为34.7%.
- 第一个玻璃体的培养产量最高 (72.6%).
- 19.5%的眼睛最初呈阴性玻璃体培养,随后呈阳性结果;24.4%的眼睛呈阳性水性培养;12.2%的眼睛呈阳性玻璃体活检/洗.
结论:
- 在具有挑战性的内眼炎病例中,重复和多样化的眼组织采样是有价值的.
- 在第一次活检时,水性水龙头最有用;重复采样有助于培养负的患者.
- 手术样本对整体培养产量和阳性有着显著的贡献.
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