脑下下出血后与克拉索森坦相关的液体保留风险因素:一项回顾性研究
Masao Sekimoto1, Toru Imai2, Yuto Suzuki1
1Department of Pharmacy, Nihon University Hospital Chiyoda-Ku, Japan.
Neurological research
|October 16, 2025
概括
高龄和早期的液体积累是接受克拉索森坦的患者体液保留的关键危险因素. 谨慎的液体平衡管理至关重要,特别是对于老年患者,以防止不良事件.
科学领域:
- 神经临界护理是指神经临界护理.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 克拉佐森坦用于预防在动脉瘤下arachnoid 出血后延迟大脑血管.
- 液体保留,包括肺,是与克拉索森坦相关的常见不良事件.
- 识别阻滞液体的危险因素对于患者的安全至关重要.
研究的目的:
- 为了确定用克拉索森坦治疗的患者体液保留的危险因素.
- 评估患者特征与与流体保留有关的不良事件之间的关联.
主要方法:
- 对患有动脉瘤下arachnoid出血的患者进行了回顾性研究.
- 使用不良事件常用术语标准 (Common Terminology Criteria for Adverse Events) 定义与液体保留相关的不良事件 v5.0.0.
- 双项逻辑回归分析以确定风险因素.
主要成果:
- 在32名患者中,有15名患者出现了水分保留.
- 液体保留的重要危险因素包括年龄 (OR:1.11) 和平均每日液体平衡 (OR:1.01).
- 确定了68岁的年龄截止值 (AUC 0.76) 和560毫升/天的液体平衡截止值 (AUC 0.90).
结论:
- 高龄和早期的液体积累是与克拉索森坦相关的液体保留的重要危险因素.
- 建议对老年患者进行密切监测和主动流体管理,以减轻风险.
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