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Updated: Jan 15, 2026

Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae
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联酶3防止氧化链断裂诱导的线粒体DNA损失,但对于复制循环化并非必不可少

Genevieve Trombly1, Afaf Milad Said1, Alexei P Kudin1

  • 1Institute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn 53127, Germany.

Nucleic acids research
|October 16, 2025
PubMed
概括

DNA连接酶3 (LIG3) 对于修复由氧化应激引起的线粒体DNA (mtDNA) 断裂至关重要. 它在细胞中的失活防止mtDNA损失,突出LIG3的作用.

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