一个系统的审查报告的不良影响与跨直接电流刺激在慢性疼痛相关的不良影响
Valentina-Fineta Chiriac1,2, Daniela-Viorica Moşoiu3,4
1Transilvania University Brasov, Faculty of Medicine, Medicine PhD School, Brasov, Romania.
American journal of therapeutics
|October 16, 2025
概括
跨直流刺激 (tDCS) 似乎对慢性疼痛是安全的,在活跃和假的组中报告了类似的副作用,如头痛和刺痛. 需要对tDCS副作用进行标准化报告.
科学领域:
- 神经科学是一个神经科学.
- 疼痛管理 疼痛管理
- 医疗器械 医疗器械
背景情况:
- 跨直流刺激 (tDCS) 越来越多地用于慢性疼痛管理.
- 虽然有效,但关于其不良影响 (AE) 的不确定性仍然存在.
- 缺乏关于慢性疼痛患者中tDCS安全性概况的系统数据.
研究的目的:
- 系统地审查和评估tDCS在慢性疼痛疾病中的安全性.
- 分析慢性疼痛中tDCS随机模拟对照试验中报告的不良反应 (AE).
主要方法:
- 对PubMed和Web of Science数据库进行了全面的系统审查.
- 包括的研究是随机的模拟控制临床试验,涉及使用tDCS治疗的慢性疼痛患者.
- 研究根据AE报告被分类为:I型 (数字数据),II型 (提到的事件),III型 (报告的缺席),IV型 (没有提到).
主要成果:
- 包括141项研究 (60项是I型,21项是II型,34项是III型,26项是IV型).
- 活体与假装组中最常见的副作用是 (26.3%与23.65%) 和皮肤发红 (17.6%与9.56%).
- 头痛和刺痛在活跃和假 tDCS 组之间没有统计学上显著的差异.
结论:
- 目前的报告表明,tDCS对于治疗慢性疼痛是安全的.
- 确定了报告和评估AE的各种方法.
- 报告tDCS不良影响的标准化程序是必要的.
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