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症状但不是生理学区分功能性消化不良与或没有重叠的胃肠道疾病
Matthias Ceulemans1, Lucas Wauters1,2, Bert Broeders1,2
1Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (ChroMeta), Katholieke Universiteit Leuven, Leuven, Belgium.
功能性消化不良 (FD) 与重叠的IBS和反流显示肠道和心理症状增加,但生理标志物相似. 中心症状的整合,而不是外围变化,可能是这些常见的肠-大脑相互作用障碍的负担.
科学领域:
- 胃肠病学 胃肠病学
- 肠-大脑相互作用
- 功能性胃肠道疾病 功能性胃肠道疾病
背景情况:
- 功能性消化不良症 (FD) 经常与刺激性肠综合征 (IBS) 和反流症重叠.
- 重叠的胃肠道 (GI) 疾病加剧心理并发症,降低生活质量.
- 关于重叠的FD综合征的生理参数的数据有限.
研究的目的:
- 调查重叠疾病和FD亚型对心理和胃肠道症状的影响.
- 评估患有FD和重叠疾病的患者的相关生理结果.
- 为了比较FD亚型之间的生理参数.
主要方法:
- 分析了202名罗马IVFD和重叠IBS/反流的患者.
- 评估了胃肠道和心理症状,以及胃肠道特有的生活质量.
- 生理学测量包括唾液皮质醇,胃排空,免疫激活和十二指肠透性.
主要成果:
- 患有重叠疾病的FD表现出显著更高的GI和心理症状严重程度.
- 所有测量到的生理参数在具有和没有重叠疾病的FD之间都是可比的.
- 在FD中,十二指甲状腺氨酸与焦虑相关,不论重叠或亚型.
结论:
- FD,IBS和反流的重叠标志着相当大的胃肠道,心理和体质症状负担.
- 关键的病理生理参数在具有或没有重叠疾病的FD之间或在FD亚型之间没有显著差异.
- 胃肠道表现的中心整合,而不是外围变化,可能解释了重叠的FD中的高症状负担.
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