估计生物年龄和与年龄相关的结果,用中文易于获取的参数
Yi Li1, Bingqi Ye2, Jialu Yang1
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, and Department of Nutrition, Sun Yat-sen University, Guangzhou, People's Republic of China.
GeroScience
|October 16, 2025
概括
一个新的衰老评估工具PCAge准确预测死亡率,并识别与年龄有关的疾病风险较高的个体. 这种具有成本效益的方法有助于人口层面的老龄化监测,特别是在资源有限的环境中.
科学领域:
- 老年学是一门学科.
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 生物衰老在个体之间有很大差异,需要可扩展和精确的评估方法.
- 目前用于评估生物年龄的方法往往缺乏在初级医疗保健机构的可访问性.
研究的目的:
- 开发和验证一种新的衰老评估工具PCAge,使用例行收集的临床,生理和实验室数据.
- 评估PCAge与时间学年龄的相关性,其对死亡率的预测性能,以及与与年龄有关的疾病的关联.
主要方法:
- 在中国健康与退休长度研究 (CHARLS) 的数据上使用主要组件分析开发了PCAge.
- 在南中国队列 (SCC) 中验证了PCAge的概括性.
- 对各种疾病的时间学年龄,死亡率预测 (C指数) 和危险比率 (HR) 的评估相关性.
主要成果:
- PCAge与时间学年龄 (r=0.86-0.88) 和预测死亡率 (C指数=0.798) 有很强的相关性.
- 生物学上较年长的个体 (PCAge > 年代年龄) 患心血管疾病,心脏病,中风,高血压和糖尿病的风险明显更高.
- 在SCC中验证的发现,确定加速衰老与高血压,糖尿病,心血管和呼吸系统疾病之间的关联,受性别,教育,收入和生活方式等因素的影响.
结论:
- PCAge是评估生物衰老状态的强大且易于使用的工具,与死亡率和疾病风险有很强的相关性.
- 该工具可以在临床疾病发病前10年识别衰老轨迹,从而使早期干预成为可能.
- PCAge为人口层面的老龄化监测提供了具有成本效益的解决方案,特别有利于资源有限的地区.
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