患有慢性病的儿童的甲状腺功能低下症:一项观察性研究
Aditi Das1, Abhijeet Saha2, Rachita Singh Dhull1
1Division of Pediatric Nephrology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
Indian pediatrics
|October 16, 2025
概括
甲状腺功能低下会影响26%的患有慢性病 (CKD) 的儿童. 这种情况在晚期CKD阶段和蛋白尿水平较高时更为普遍,这表明功能和甲状腺健康之间存在联系.
科学领域:
- 儿科病学 儿科病学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 慢性病 (CKD) 是儿童的重大健康问题.
- 甲状腺功能障碍,特别是甲状腺功能低下症,会影响整体健康和疾病进展.
- 儿童CKD人群中甲状腺功能低下的患病率需要进一步调查.
研究的目的:
- 为了确定诊断为慢性病的儿童中甲状腺功能低下的患病率.
- 探索甲状腺功能低下症和CKD阶段之间的关联.
- 为了研究小儿慢性病患者甲状腺功能低下和蛋白尿水平之间的关系.
主要方法:
- 进行了一项基于医院的观察性研究.
- 50名1至18岁的儿童被诊断患有慢性病.
- 测量血清自由甲状腺素和甲状腺刺激激素水平以诊断甲状腺功能低下症. 评估了尿蛋白与肌素的比率 (UP:UC).
主要成果:
- 在50名儿童中,13名 (26%) 被诊断为甲状腺功能低下症.
- 甲状腺功能低下症的发病率在CKD 2/3阶段为23%,在CKD ≥4.4阶段为27%.
- 甲状腺功能低下症观察到20%的患者UP:UC在0.2和<2之间,和39.1%的患者UP:UC>2.2. 没有发现可检测的甲状腺过氧化酶抗体.
结论:
- 甲状腺功能低下症是患有慢性病的儿童常见的并发症.
- 甲状腺功能低下的患病率随着晚期CKD阶段和较高程度的蛋白尿增加.
- 在儿科CKD患者中,建议定期查甲状腺功能低下症,特别是那些具有显著蛋白尿症的患者.
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