研究小组的性别多样性和临床试验招生
Harsh Gupta1, Anupam B Jena2,3,4, Eric C Sun5
1Department of Economics, Stanford University, Stanford, California.
JAMA network open
|October 16, 2025
概括
由女性首席研究员领导的临床试验中,女性参与者的比例更高. 这表明,研究领导层中的性别多样性可以帮助解决临床试验招生中的不平等问题.
科学领域:
- 生物医学科学 生物医学科学
- 临床研究 临床研究
- 健康 公平 卫生 公平
背景情况:
- 妇女在临床试验中的不足仍然是生物医学研究中的一个重大问题.
- 研究团队,特别是主要研究人员 (PI) 之间的性别多样性对参与试验的影响尚不清楚.
研究的目的:
- 调查主要研究人员的性别与临床试验中女性的比例之间的关联.
- 探索PI性别可能影响参与者人口统计学的潜在机制.
主要方法:
- 在ClinicalTrials.gov注册的10,708项临床试验的横截面分析 (2007年至2021年期间的注册).
- 对比了由女性PI领导的试验中女性参与者的比例与男性PI的比例,调整了混因素.
- 根据PI的性别评估调查员的决策,例如包括孕妇和雇用女性研究人员,基于PI的性别.
主要成果:
- 与男性PI试验 (46.9%) 相比,与女性PI试验的试验中,女性PI的平均入学率更高 (54.1%),调整后的差异为7.3%.
- 由女性PI领导的试验显示,女性研究人员比例较高,不太可能排除孕妇.
- 这些发现具有统计学意义 (P < .001).
结论:
- 主要研究人员中性别多样性的增加与临床试验中女性入学率的提高有关.
- 女性PI可以通过雇佣更多的女性员工和对孕妇参与者不那么严格来促进更具包容性的试验环境.
- 这些结果突出了减轻临床研究参与中的基于性别的不平等现象的潜在策略.
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